Hypothermic Machine Preservation in Liver Transplantation Revisited: Concepts and Criteria in the New Millennium
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Hypothermic Machine Preservation of the Liver: State of the Art
Purpose of Review In this review, we highlight which livers may benefit from additional treatment before implantation and describe the concept of hypothermic machine liver perfusion. Furthermore, we explain why cold oxygenated perfusion concepts could potentially lead to a breakthrough in this challenging field of transplantation. Accordingly, we summarize recent clinical applications of differ...
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Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and current strategies to assess graft quality during cold perfusion. Next, we provide an overview of po...
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Donation after circulatory death (DCD) is a promising solution to the critical shortage of donor graft tissue. Maintaining organ viability after donation until transplantation is essential for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in clinical practice. However, ischemic damage present in DCD grafts jeopardizes organ viabil...
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Static cold storage is currently the most used method of organ preservation worldwide. However, cutting edge technology and dramatic changes in the donor pattern have lately renewed the interest toward hypothermic machine perfusion. Marginal and cardiac death donors show higher rates of primary non function and delayed graft function compared to standard criteria donors. In this setting, machin...
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T acceptance of livers of limited quality has been the predominant way to increase the donor pool in recent years. Unfortunately, this practice increases the risk afflicted with the procedure, because these organs are more prone to preservation induced injury and ultimately allograft damage and dysfunction. Accordingly, morbidity and mortality are increased in the context of marginal liver allo...
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